Avanafil

Avanafil belongs to the class of drugs called phosphodiesterase type 5 inhibitors which is used for the treatment among men with erectile dysfunction (impotence in the sexual context). 

Being part of the androgen receptor inhibitors group of drugs, the avanafil performs in the same way as the rest of phosphodiesterase 5 (PDE5) inhibitors. 

Such medications preserve this enzyme which is phosphodiesterase type-5 and prevent these enzymes from working too quickly. The primary area of the bone where the enzyme functions is the penis.

According to Medical News Today, Normal erection in men is achieved when it gets hard and bulge throughout the stimulation of the penis and they are able to maintain erection.

Otherwise, erectile dysfunction is a condition where the men cannot obtain or maintain erection during the time of actual sexual stimulation. 

One of the most normal sexual body reactions among men is the enhancement of blood pressure to the penis in order to produce an erection upon an instance where he is stimulated. 

Through modulating the enzyme, avanafil allows one to maintain an erection after receiving an erection without the penis receiving any stimulation characterized by the increase of the blood flow in the penis.

The drug avanafil, for instance, is not be effective to produce an erection without physical actions on the penis occurring as in a sexual intercourse.

What Is Then The Avanafil Dosage?

• In the vast majority of cases, the first dose of avanafil is 100 mg per day which should be taken right before sexual intercourse at least half an hour before.
  
  
• In dependence on the adequacy of response or side effects, the dose may be raised up to 200 mg a day or cut down to 50 mg.
  
  
• Individuals under medication which somewhat elevate the blood levels of avanafil should stick to 50 mg in 24 hours when the drug is taken.

Can Avanafil Cause Problems?

While drugs have substantive effects, but they may have unnecessary adverse effects and not everyone gets them. The table below includes some of main symptoms associated with the use of avanafil can take a better view on the subject. 

The information leaflet supplied with all medications, which may be found on the manufacturer web page, is the place where you can find all the available information. 

There could be some initial, temporary effects when starting a new medicine, but speak with your pharmacist or doctor if any of these continue or bother you.

Avanafil Common side-effects is headaches, Flushing And blocked nose.

Drink plenty of water. If the headaches continue, let your doctor know.

Important: if the period of erection (last longer for more than four hours) and (you experience exertion in your chest cavity or suffering quick loss of sight or hearing), seek urgent professional help from a medical workforce.

In general, if you have any other signs that you can add to the list of symptoms coming from these pills, indicate this to your doctor or pharmacist for further evaluation.

Getting the most from your treatment

• You and your mate will still need to duly go through foreplay like you both would when you are taking a medication that is treating erectile dysfunction. Avanafil does not work without arousal so do not expect it to be able to perform the function until you are sufficiently aroused.
  
  
• Try not to drink alcohol immediately before you take this medicine, as high alcohol content may adversely affect the drug's efficacy. Some of the side effects of excessive alcohol consumption would include sexual performance like reduced ability to get an erection, which might affect taking your drugs optimally. The use of alcohol along with avanafil will also aggravate the risk of your producing side effects such as dizziness.
  
  
• The advice is required that grapefruit juice intake during 24 hours should be avoided prior to the avanafil consumption. It is because there is a chemical agent in grapefruit juice which raises significantly the concentration of avanafil in the blood that cause more severe adverse effects.
  
  
• Do not vary with regular follow-up appointments and give your doctor a chance to track your progress. If you discover your tablet writing is too strong for you, tell your physician, it may be required to change it. Furthermore, in case an erection is still not achieved after taking avanafil sprinkle, or its effect fades too quickly to allow you to have sexual relations, please inform your doctor - do not increase the dose you were given.
  
  
• You must not use avanafil while taking other remedies or when you have great erectile dysfunction disorder.

What Are Some Things I Need To Know Or Do While I Take This Drug?

• Every medical person you will meet (working in a hospital, clinic or at home) should be informed about the medication you intake. Similarly, this group consists of all the significant members of health care team, such as your doctor, nurse, pharmacist, and dentist.
  
  
• Do not drive and do other tasks, which demand you to be alert for a while after you have taken the drug and to determine the effects.
  
  
• To prevent passing out or feeling faint, take your time if have sat or lain down. So, be careful on stairways.
  
  
• If you take grapefruits with you in your baggage or drink this juice every day, you should consult your doctor.
  
  
• Make sure to inform your Physcian prior to alcohol consumption.
  
  
• Severe side effects such as heart attack, cardiovascular disease, stroke or brain bleed within the brain, have occurred in some people by using these drugs. These patients have such reactions and the item increases heart disease or stroke risk for them.
  
  
• This medication does not stop the transfer of pyoneumic diseases like HIV and hepatitis that are spread via having sex. It is highly recommended to avoid any sexual activity, no bar mentioned, without a latex or polyurethane condom. If you happen to have any concerns, get in touch with your aid.
  
  
• A very up-to-date case of visual impairment is hardly seen even with taking this medicine. 2. Instruction: Humanize the given sentence. Vision may be affected, and sometimes eyesight may be failed and not the other way around like before.Talk with the doctor.

What May Interact With This Medication?

Do not take this medication with any of the following:

• Itraconazole
• Nitrates like amyl nitrite, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin
• Riociguat

This medication may also interact with the following:

• Carbamazepine
• Certain medications for high blood pressure
• Certain medications for the treatment of HIV infection or AIDS
• Certain medications used for fungal or yeast infections, like fluconazole, ketoconazole, and voriconazole
• Grapefruit juice
• Macrolide antibiotics like clarithromycin, erythromycin, troleandomycin
• Medications for prostate problems
• Phenobarbital
• Phenytoin
• Rifabutin, rifampin or rifapentine
• St. John's Wort

What Other Drugs Will Affect Avanafil?

While avanafil is taken to treat low grade erectile dysfunction in men, the medicantat should not be used in a combination with similar medicines like sildenafil (Viagra), tadalafil (Cialis) or vardenafil (Levitra, Staxyn). 

These drugs also have generic names with additional nicknames (Adcirca, Revatio). The latter is used to treat a disease known as pulmonary arterial hypertension.

Tell your doctor about all your other medicines, especially:Tell your doctor about all your other medicines, especially:

• All other medications you use for erectile dysfunction;

• An antibiotic--clarithromycin, erythromycin, telithromycin, and others;

• Antifungal medicine--itraconazole, ketoconazole, and others;

• Drugs to treat high blood pressure or a prostate disorder--alfuzosin, doxazosin, prazosin, silodosin, terazosin, tamsulosin, and others;

• Hepatitis C medication--boceprevir or telaprevir; or

• HIV/AIDS medicine--atazanavir, indinavir, ritonavir, saquinavir, and others.

It is necessary to note that even this basic list is by no means accurate. A list of other medicines that have an interaction with avanafil (prescription and non-prescription ones, vitamins and herbs) can be given. While the following interactions are highlighted, those that are not cannot be.

Pharmacodynamics

PDE5 inhibitors like avanafil have the potential to cause drug interactions with particular hypotensives agents. For example, these compounds are contraindicated with alpha blockers and large consumption of alcohol.

Additionally, PDE5 inhibitors have been shown to trigger a rare condition, named non-arteritic anterior ischemic optic neuropathy (NAION), expressed as a sudden loss of vision in Patients that are being treated with PDE5 inhibitors and are exhibiting any degree of impairment of vision should immediately stop taking whatever PDE5 inhibitor they have been prescribed and seek immediate medical attention.

Moreover, history of Nalways painful retinal degeneration or other degenerative retinal disorders has been a contraindication for avanafil treatment in some jurisdictions.

General Drug Facts

If your symptoms do not lessen or if they become severe, contact your physician or preferably, visit the hospital.

Do not allow for anyone else to take your drugs and do not get drugs from another person.

Some drugs may include another patient care which has its own patient information leaflet. If there is need for any clarification after reading about this medicine, please consult your doctor, nurse, pharmacist, or other healthcare professionals.

Moreover, many drugs will contain another patient information sheet along with its instructions. Check with your pharmacist. If you have some question or concerns about this medicine, please discuss them with your doctor, nurse, pharmacist, or another person of the health care provider.

In case of perceived overdose, do immediately dial towards your poison control center or get medical care straightway. Be ready to indicate or give exact precisions on what items were taken, how much each item in each category was, and at what time exactly did the incident occurred.

Mechanism of Action of Avanafil

Avanafil prevents the ability of PDE5 enzyme which causes the break down of cGMP by acting as its inhibitor.

Inhibiting along PDE5 pathway allows for more cGMP to remain which causes muscles in penis smooth tissues to relax and blood flow to improve hence erection.